刘庆超


个人简介


姓名:刘庆超

性别:男

籍贯:山东莒南

职称:教授/博士生导师/制药系主任

学位:医学博士

所在院系: 威尼斯9499登录入口制药工程系

电子邮件liuqc21@nwu.edu.cn

通信地址: 西安市太白北路229号威尼斯9499登录入口, 710069

研究方向: 药物化学,天然活性化合物(抗肿瘤、抗病毒及抗糖尿病活性分子)的分离、结构鉴定、合成及构效关系研究;有机合成方法学研究。

个人主页: https://faculty.nwu.edu.cn/QingchaoLiu/

教育与工作经历

200009月至200407月,中国海洋大学药学专业本科学习,获学士学位;

200503月至200508月,中国科学院上海有机化学研究所俞飚院士组研究助理;

200509月至201006月,中国海洋大学药物化学专业硕博连读,获博士学位;

201007月至今,威尼斯9499登录入口制药工程系任教;

201502月至201702月,香港理工大学应用生物与化学科技学系,博士后(香江学者)。


学术团队、兼职

中国化学会会员、中国药学会会员、香港学者协会会员


荣誉称号

2015年入选陕西省青年科技新星

2014年入选人社部香江学者

2014年入选威尼斯9499登录入口优秀青年学术骨干支持计划


教学工作

课程教学

[1] 讲授本科生专业课《制药工艺学》

[2] 讲授硕士研究生课程《现代制药工艺学》

[3] 讲授博士研究生课程《制药工程前沿技术》

主持教学项目

[1]  教育部2022年第一批产学合作协同育人项目,新工科背景下的制药工程专业人才培养模式探索,220605042193453,主持。

[2]  教育部2021年第二批产学合作协同育人项目,基于“新工科”教育背景下制药工艺学课程群及教学团队建设,202102403005,主持。

[3]  教育部2019年第二批产学合作协同育人项目,基于校企合作的制药工程专业本科生人才实践基地建设的探索和实践,201902195034,主持。

[4]  威尼斯9499登录入口,基于工程教育专业认证的制药工程本科专业建设,XM05190283,主持

出版教材

[1]  刘守信主编,刘庆超参编,《药物合成反应基础》,化学工业出版社,2012年(国家级精品课程教材)。

[2]  宋航主编,刘庆超参编,《天然产物技术》,高等教育出版社,2016年。


科研工作

主持的纵向科研项目(课题):

[1] 国家自然科学基金面上项目,基于PTP1B蛋白酶的新型齐墩果酸N-苷糖化合物的设计、合成及抗II型糖尿病分子机制研究,220782632021/01-2024/1263万元,在研,主持。

[2] 国家重点研发计划子课题,天然活性产物衍生物修饰合成,2021YFC21015002021/06-2024/0570万元,在研,主持。

[3] 国家重点研发计划子课题,维生素生物合成关键限速酶的改造,2022YFC21061002023/01-2025/1266万元,在研,主持。

[4] 陕西省科技厅重点研发项目,基于PTP1B靶标的新型齐墩果酸N-糖苷先导化合物的研究与开发,2021SF-1162021/01-2022/127万元,在研,主持。

[5] 威尼斯9499登录入口防治新型冠状病毒肺炎紧急科研专项引导基金,芳基二酮酸Des化合物的设计、合成及对新型冠状病毒的抑制活性研究,2021/01-2022/125万元,在研,主持。

[6] 陕西省科技厅自然科学基金,新型氟代PTP1B抑制剂的设计、合成及功能研究,2018JM20602018/01-2019/125万元,结题,主持。

[7] 陕西省教育厅自然科学基金,皂苷类抑制剂的合成及抗糖尿病活性研究,15JK17172015/06-2016/122万元,结题,主持。

[8] 陕西省青年科技新星项目,三萜皂苷的化学合成及抗糖尿病活性研究,2015KJXX-282015/05-2017/0610万元,结题,主持。

[9] 陕西省自然科学基金,2014JQ2069、齐墩果烷型三萜皂苷PTP1B抑制剂的设计合成及构效关系研究,2014/01-2015/125万元,结题,主持。

[10] 香江学者项目,XJ2014014,生物活性海洋天然产物的全合成,2015/03-2017/0360万元,结题,主持。

[11] 中国博士后第6批特别资助项目,2013T60887、新型齐墩果酸糖苷PTP1B抑制剂的合成及构效关系研究,2013/03-2014/0515万元,结题,主持。

[12] 中国博士后科学基金第51批面上项目,2012M512023、旋覆花内酯糖苷Bcl-2抑制剂的合成及抗肿瘤活性研究,2012/03-2013/115万元,结题,主持。

[13] 2011年度教育部高等学校博士点基金联合资助课题新教师类项目,20116101120025,齐墩果酸皂苷PTP1B抑制剂的设计合成及构效关系研究,2012/01-2014/124万元,结题,主持。

[14] 陕西省教育厅自然科学基金,11JK0676,黄酮糖缀合物的合成及抗肿瘤活性研究,2011/07-2013/072万元,结题,主持。

主持的横向科研项目(课题):

[1]  广州光亚新汉方科技有限公司,视黄醇及衍生物降刺激的作用机制研究,2023/09-2024/0933.9万元,在研,主持。

[2]  深圳乾研药物研发科技有限公司,抗肿瘤小分子药物的中试工艺放大研究,2023/03-2027/03100万元,在研,主持。

[3] 山东道箴医药科技有限公司,抗病毒药物的中试工艺放大研究,2020/05-2023/11100万元,在研,主持。

[4] 山东道箴医药科技有限公司,抗糖尿病药物的中试工艺放大研究,2019/11-2022/11150万元,在研,主持。

[5] 福建同舟济生物科技有限公司,基于高纯烟碱药物中间体的智能靶向切割关键技术,2019/07-2024/0790万元,在研,主持。

[6] 西安吉泰药业有限公司,原料药理化参数的测试与分析,2021.07-2023.0610万元, 结题,主持。

[7] 南京予善化工有限公司,一种胺基葡萄糖中间体的合成,2017/09-2018/0910万元,结题,主持。

[8] 华南理工大学横向委托项目,XD1012,系列甘油酯化合物的研究开发,2016/09-2017/1210万元,结题,主持。

[9] 延炼集团横向委托项目,UG13121,固体酸合成丙烯酸异冰片酯的合成工艺研究,2013/5-2014/720万元,结题,主持。

参与的纵/横向科研项目(课题):

[1] 国家自然科学基金面上项目,31570348,基于PPAR等靶点的植物-水曲柳种子抗糖尿病功能分子研究,2014/1-2017/1265万元,结题,第二。

[2] 解放军总后勤部项目,UG12161,汉麻叶化学成分的分离、结构修饰及生物活性研究,2013/5-2015/12100万元,结题,第二

[3] 榆林市科技厅产学研项目,沙旋复花、紫穗槐及闹羊草深度开发利用,2013/5-2015/510万元,结题,第二

[4] 浙江杭康制药有限公司,多烯磷脂酰胆碱的纯化工艺研究,2012/3-2013/39.6万元,结题,第二

[5] 陕西恒源生物化工有限公司,黄姜中黄色素的提取纯化工艺研究,2012/5-2013/510万元,结题,第二

主要学术论文:

[1] Zhang, J. J.; Tong, Y. L.; Lu, X.; Dong, F. M.; Ma, X. X.; Yin, S. Y.; He, Y.; Liu, Y. H.; Liu, Q. C.*; Fan, D. D. A derivant of ginsenoside CK and its inhibitory effect on hepatocellular carcinoma. Life Scieces 304, 120698, 2022. (SCI)

[2] Liu, H.; Li, G. L.; Peng, Z. Y.; Zhang, S. S.; Zhou, X.; Liu, Q. C.; Wang, J. F.; Liu, Y. H.; Jia, T. Z. Tagging peptides  with a redox responsive fluorescent probe enabled by photoredox difunctionalization of phenylacetylenes with sulfinates and disulfides. J. Am. Chem. Soc. Au, 2(12), 2821-2829, 2022. (SCI)

[3] Tong, Y. L.; Song, X. P.; Zhang, Y. X.; Xu, Y.; Liu, Q. C.* Insight on structural modification, biological activity, structure-activity relationship of PPD-type ginsenoside derivatives. Fitoterapia 158, 105135, 2022. (SCI)

[4] Ye, X. P.; Zhang, Y. X.; Song, X. P.; Liu, Q. C.* Research progress in the pharmacological effects and synthesis of nicotine. ChemistrySelect 7, e202104425, 2022. (SCI)

[5] Bai, J. X.; Wang, T. X.; Dai, B. T.; Liu, Q. C.*; Yu, P. Y.; Jia, T. Z. Radical Anion-Promoted Chemoselective Cleavage of Csp2-S Bond Enables Transition-Metal-Free Formal Cross-Coupling of Aryl Methyl Sulfones with Alcohols. Org. Lett., 23, 5761-5765, 2021. (SCI 1区, IF 6.005, Top期刊)

[6] Zhou, X.; Peng, Z. Y.; George Wang, P.; Liu, Q. C.*; Jia, T. Z. Atom Transfer Radical Addition to Styrenes with Thiosulfonates Enabled by Synergetic Copper/Photoredox Catalysis. Org. Lett., 23(3), 1054-1059, 2021. (SCI 1, IF 6.005, Top期刊)

[7] Han, W. R.; Cai, J.; Zhong, W. M.; Xu, G. M.; Wang, F. Z.; Tian, X. P.; Zhou, X. J.; Liu, Q. C.*; Liu, Y. H.; Wang, J. F. Protein tyrosine phosphatase 1B (PTP1B) inhibitors from the deep-sea fungus Penicillium chrysogenum SCSIO 07007. Bioorg. Chem., 96, 10364, 2020. (SCI 1, IF: 5.275, Top期刊)

[8] Li, G. L.; Yexenia Nieves-Quinones; Zhang, H.; Liang, Q. J.; Su, S. S.; Liu, Q. C.; Marisa C. Kozlowski, Jia, T. Z. Transition-Metal-Free Cross-Coupling Reactions of Aryl Methyl Sulfoxides and Alcohols via a Nucleophilic Activation of C-S Bond. Nature Communications, 11, 2890, 2020. (SCI 1, IF: 14.919, Top期刊)

[9] Wang, C.; Zhang, H.; Lucille A. Wells; Liu, T.; Meng, T. T.; Liu, Q. C.; Patrick J. Walsh; Marisa C. Kozlowski; Jia T. Z. Autocatalytic photoredox Chan-Lam coupling of free diaryl sulfoximines with arylboronic acids. Nature Communications, 12, 932, 2021. (SCI 1, IF: 14.919, Top期刊)

[10] Liu, Q. C.; Liu, L. L.; Ranjala Ratnayake; Hendrik Luesch; Guo, Y. A; Ye, T. Nine-step total synthesis and biological evaluation of rhizonin A. Chinese Journal of Chemistry, 38, 1280-1284, 2020. (SCI 2区,IF: 6.000)

[11] Guo, T. T.; Song, Y. M.; Lu, Y. H.; Li, G. L.; Liu, T.; Han, W. R.; Song, W. G.; Yang, C. C.; Li, F. H.; Liu, Q. C*. Total synthesis and anticancer activity of the natural oleanolic acid bidesmoside saponin, albidoside A, isolated from the roots of Acacia albida. J. Chem. Res., 44(1-2), 42-49, 2020. (SCI)

[12] Guo, T. T.; Song, M. M.; Han, W. R.; Zhu, J. H.; Liu, Q. C*; Wang, J. F. New N-methyl-4-quinolone alkaloid and citrinin dimer derivatives from the sponge-derived fungus Penicillium sp. SCSIO 41303. Phytochem. Lett., 46, 29-35, 2021.(SCI)

[13] Li, G.; Wang, G. H.; Tong, Y. L.; Zhu, J. H.; Yun, T. T.; Ye, X. P.; Li, F. H.; Yuan, S. L.; Liu, Q. C.*. Concise synthesis and antidiabetic activity of  natural flavonoid glycosides, oroxins C and D, isolated from the seeds of Oroxylum indium. J. Chem. Res., 1-2, 68-75, 2021.(SCI)

[14] Liu, L. L.; Guo, Y. A.; Liu, Q. C*; Ranjala Ratnayake; Hendrik Luesch; Ye, T. Total synthesis of Endolides A and B. Synlett. 30, 2279-2284, 2019 (SCI)

[15] Song, Y. M.; Guo, T. T.; Liu, Q. C*.; Li, F. H.; Song, W. G. A sequential one-pot strategy for the synthesis of triterpenoid saponins in ionic liquid [emim][OTf]. J. Chem. Res., 43, 20-25, 2019. (SCI)

[16] Guo, T. T.; Liu, Q. C*.; Hou, P. B.; Li, F. H.; Guo, S.D.; Song, W. G.; Zhang, H.; Liu, X. Y.; Zhang, S. Y.; Zhang, J. C.; Ho, C. T.; Bai, N. S. Stilbenoids and cannabinoids from the leaves of Cannabis sativa f. sativa with potential reverse cholesterol transport activity. Food Funct., 9, 6609-6618, 2018. (SCI 1区,IF: 5.396, Top 期刊)

[17] Bai, L.; Liu, Q. C.; Cen, Y. J.; Huang, J. P.; Zhang, X. X.; Guo, S.; Zhang, L.; Guo, T. T.; Ho, C. T.; Bai, N. S.* A new sesquiterpene lactone glucoside and other constituents from Inula salsoloides with insecticidal activities on striped flea beetle (Phyllotreta striolata Fabribricius). Nat. Prod. Res., 32(5), 552-557, 2018. (SCI)

[18] Tian, H.; Liu, Q. C.; Qin, S. C.; Zong, C. L.; Zhang, Y.; Yao, S. T.; Yang, N. N.; Guan, T.; Guo, S. D*. Synthesis and cardiovascular protective effects of quercetin 7-O-sialic acid. J. Cell. Mol. Med. 21, 107-120, 2017. (SCI)

[19] Liu, Q. C*.; Guo, T. T.; Li, F. H.; Li, D. Concise synthesis of a new triterpenoid saponin from the roots of Gypsophila oldhamiana and its derivatives as α-glucosidase inhibitors. New J. Chem., 40, 9537-9549, 2016. (SCI)

[20] Liu, Q. C*.; Guo, T. T.; Li, D.; Li, W. H. Concise synthesis and antidiabetic effect of three natural triterpenoid saponins isolated from Fadogia ancylantha (Makoni tea). Res. Chem. Intermed., 42, 1611-1626, 2016. (SCI)

[21] Bai, L.; Guo, S.; Liu, Q. C.; Cui, X. Q.; Zhang, X. X.; Zhang, L.; Yang, X. W.; Hou, M. W.; Ho, C. T.; Bai, N. S*. Characterization of nine polyphenols in fruits of Malus pumila Mill by high-performance liquid chromatography. J. Food Drug Anal. 24, 293-298, 2016. (SCI)

[22] Bai, L.; Zhang, H.; Liu, Q. C.; Zhao, Y.; Cui, X. Q.; Guo, S.; Zhang, L.; Ho, C. T.; Bai, N. S.*. Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba. Food Funct. 7, 2870-2877, 2016. (SCI)

[23] Bai, L.; Jiang, M.; Guo, S.; Liu, Q. C.; Zhang, X. X.; Tian, X.; Zhang, L.; Ho, C. T.; Bai, N. S.*. Simultaneous quantification of six sesquiterpene lactones and a flavonoid in the whole life stage of Inula salsoloides by high performance liquid chromatography. Anal. Methods 8, 3587-3591, 2016. (SCI)

[24] Feng, Z. L.; Wu, S. P.; Li, W. H.; Guo, T. T.; Liu, Q. C*. Concise synthesis and antidiabetic effect of three natural triterpenoid saponins isolated from Fadogia ancylantha (Makoni tea). Helv. Chim. Acta, 98, 1254-1266, 2015. (SCI)

[25] Guo, T. T.; Wu, S. P.; Guo, S.; Bai, L.; Liu, Q. C.*; Bai, N. S*. Synthesis of a trisaccharide related to the cytotoxic triterpenoid saponins isolated from the bark of Albizia procera. Arch. Pharm., 348, 615-628, 2015. (SCI)

[26] Liu, Q. C.; Guo, T. T.; Li, D.; Li, F. H.; Li, W. H*. Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors. Eur. J. Med. Chem. 79, 34-46, 2014. (SCI)

[27] Liu, Q. C.; Guo, T. T.; Zhang, C.; Sun, J.; Li, W. H*. Synthesis of a trisaccharide related to the cytotoxic triterpenoid saponins isolated from the bark of Albizia procera. Helv. Chim. Acta, 97, 361-368, 2014. (SCI)

[28] Yang, H. X.; Liu, Q. C.; Zhao, L.; Yuan, Y.; Fan, D. D.; Deng, J. J.; Zhang, R. J*. Fluorescence spectroscopic studies on the interaction of oleanolic acid and its triterpenoid saponins derivatives with two serum albumins. J. Solution Chem. 43, 774-786, 2014. (SCI)

[29] Liu, Q. C.; Guo, T. T.; Zhang, L.; Yu, Y.; Wang, P.; Yang, J. F.; Li, Y. X*. Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors. Eur. J. Med. Chem., 63, 511-522, 2013. (SCI)

[30] Liu, Q. C.; Liu, H. C.; Zhang, L.; Guo, T. T.; Wang, P.; Geng, M. Y.; Li, Y. X*. Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives. Eur. J. Med. Chem., 64, 1-15, 2013. (SCI)

[31] Liu, Q. C.; Guo, T. T.; Guo, S. D.; Li, W. H*.; Li, D. Synthesis and evaluation of four hederagenin glycosides as -glucosidase inhibitor. Helv. Chim. Acta, 96 (1),142-149, 2013. (SCI)

[32] Li, D.; Li, Z.; Li, W. H*.; Liu, Q. C.; Feng, Z. L.; Fan, Z. Hydrotreating of low temperature coal tar to produce clean liquid fuels. J. Anal. Appl. Pyrol. 100, 245-252, 2013. (SCI)

[33] Liu, Q. C.; Guo, T. T.; Li, W. H*.; Li, D.; Feng, Z. L. Synthesis and evaluation of benzophenone O-glycosides as a-glucosidase inhibitors. Arch. Pharm., 345 (10), 771-783, 2012. (SCI)

[34] Liu, Q. C.; Li, W. H*.; Guo, T. T.; Li, D.; Fan, Z.; Yan, S. H. Efficient synthesis of a bis-glycosyl kaempferol from Fagonia taeckholmiana. Chem. Lett., 3, 324-325, 2011. (SCI)

[35] Liu, Q. C.; Guo, T. T.; Fan, Z.; Li, D.; Li, W. H. First total synthesis of two new heterocyclic compounds: bretschneiderazines A and B. Chin. Chem. Lett., 22, 801-803, 2011. (SCI)

[36] Liu, Q. C.; Fan, Z.; Li, D.; Li, W. H*.; Guo, T. T. Facile synthesis of several oleanane-type triterpenoid saponins. J. Carbohydr. Chem., 29, 386-402, 2011. (SCI)

授权发明专利:

[1] Liu, Q. C.; Liu, L. L.; Liu, T.; Zhu, J. H.; Tong, Y. L. Method for preparation of cyclic heptapeptide rhizonin. Faming Zhuanli Shenqing, CN 110655558, 2020.

[2] Liu, Q. C.; Lu, Y. H.; Song, M. M.; Bai, J. X.; Zhou, X.; Tong, Y. L; Zhu, J. H.; Yun, T. T. Total synthesis of natural product coumarin tyramine glucoside compound. Faming Zhuanli Shenqing, CN 110642906, 2020.

[3] Liu, Q. C.; Guo, T. T.; Bai, N. S.; Liu, L. L.; Li, G. L.; Liu, T.; Han, W. R.; Lu, Y. H.; Zhou, X.; Bai, J. X. Jujube flower extract, and its application as antibacterial material. Faming Zhuanli Shenqing, CN 108912200, 2018.

[4] Liu, Q. C.; Bai, N. S.; Guo, T. T.; Liu, L. L.; Li, G. L.; Liu, T.; Han, W. R.; Lu, Y. H. Oleanane type nitrogen glycoside compounds useful in treatment of diabetes mellitus and its preparation. Faming Zhuanli Shenqing, CN 108530508, 2018.

[5] Liu, Q. C.; Bai, N. S.; Guo, T. T.; Liu, L. L.; Li, G. L.; Liu, T.; Han, W. R.; Lu, Y. H. Stilbene compound from hemp leaf and its application in preparing medicine for lowering lipid. Faming Zhuanli Shenqing, CN 109010325, 2018.

[6] Bai, N. S.; Guo, S.; Liu, Q. C.; Zhang, Y. T.; Zhang, L.; Bai, L.; Zhang, X. X.; Tian, X. Fraxinus rhynchophylla seed chemical composition standardized extract and its preparation method and application. Faming Zhuanli Shenqing, CN 105748496, 2016.

[7] Bai, N. S.; Bai, L.; Wu, Y.; Liu, Q. C.; Zhang, L.; Guo, S.; Cui, X. Q.; Jiang, M. A jujube leaf standardized extract and its preparation and application. CN 105687367, 2016.

[8] Bai, N. S.; Liu, Q. C.; Zhang, Y. T.; Xue, W. M.; Bai, L.; Zhang, L.; Guo, T. T.; Wen, H. Y.; Guo, S. Method for extracting secoiridoid glycoside-series compound as hypoglycemic substance from Fraxinus rhynchophylla hance seeds. CN 105687367, 2015.

[9] Bai, N. S.; Liu, Q. C.; Bai, L.; Yang, X. W.; Zhang, L.; Guo, T. T.; Hou, M. W.; Guo, J.; Cui, X. Q. Standardized malic extract, preparation and analysis method. CN 104730174, 2015.

[10] Bai, N. S.; Liu, Q. C.; Bai, L.; Zhang, L.; Guo, T. T.; Cui, X. Q.; Wu, Y.; Tian, X.; Jiang, M.; Zhang, X. X. One kind of standardized jujube extract, its preparation and analysis methods. CN 104585651, 2015.

[11] Bai, N. S.; Zhang, J. C.; Liu, Q. C.; Zhang, L.; Bai, L.; Hou, Y. F.; He, J. F.; Zhang, H.; Liu, X. Y.; Zhang, S. Y. New compounds separated from Cannabis sativa leaves and separation method therefore. CN 104447673, 2015.

[12] Liu, Q. C. Process for preparation of (α/β)-D-fucose. Faming Zhuanli Shenqing, CN 103483396, 2014.